Prof. Dr. med. Holger Moch

Current positions

• Professor of Pathology
  (Faculties of Medicine)

• Director, Medical Division Pathology and Laboratory Medicine, University Hospital Zurich

Education

• 1982 – 1988 Humboldt-University, Faculty of Medicine, Charité, Berlin (M.D.)

Licensure and Certification

• 1988 German Federal Licence (Approbation)
• 1988 Doctor of Medicine (Experimental Thesis) – Humboldt-University of Berlin, Germany
• 1993 German Board Certificate in Anatomical Pathology, (Aerztekammer Berlin, Germany)
• 1998 Habilitation (University Lecturer) – University Basel, Switzerland
• 2004 Swiss Board Certificate in Molecular Pathology (FMH Subtitel Molekularpathologie)

Fellowships, Post-Doctoral Training, Academic and Spital Appointments

• 1988 – 1990 Resident
  University Clinics, Institute for Pathology, Institute for Forensic Medicine, Charité, Berlin, Germany
• 1990 – 1993 Pathology Resident
  Institute for Pathology, University of Basel; Basel, Switzerland
• 1994 Research Fellow
  Division of Molecular Cytometry, Department of Laboratory Medicine, University of California San Francisco; San Francisco; USA
• 1995 Staff Physician (Oberarzt); Institute for Pathology, University Hospital; Basel, Switzerland
• 2001 Visiting Fellow
  Harvard Medical School, Department of Pathology, Massachusetts General Hospital Boston, Massachusetts, USA
• 2001 Associate Professor of Pathology, University Basel, Switzerland
• 2004 Full Professor of Pathology, University Zürich, Switzerland

Major Administrative Responsibilities

• 2001 Director, Surgical Pathology Unit (Histology, Immunohistochemistry and Autopsy), Institute for Pathology, University Hospital Basel
• 2004 Chairman, Institute of Surgical Pathology, University Hospital Zürich, Switzerland
  Clinical Co-Director, Department Pathology, University Zürich
• 2010 Director, Medical Division Pathology and Laboratory Medicine, University Hospital Zurich

Awards and Honors

• 1987 Robert-Koch-Prize (Thesis Award), Humboldt-University-Charité, Berlin
• 1995 "Seminars in Diagnostic Pathology Prize" of the European Society of Pathology
• 1998 Roche Research Foundation Award (Trainee H. Bissig)
• 2007 Member of the "German Academy of Sciences Leopoldina"

Editorial Activities

• Advances in Anatomic Pathology
• Virchows Archiv
• Molecular Oncology

Reviewer for
on ad hoc basis

• Nature Medicine
• Cancer Research
• American Journal Pathology
• Clinical Cancer Research
• Journal Pathology
• Modern Pathology
• Human Pathology
• Kidney International
• Virchows Archiv
• Oncogene
• Pathology Research and Practice
• International Journal of Cancer
• Journal of Urology 
• Swiss Medical Weekly
   
  and others

Professional Societies

• Aerztekammer Berlin (Germany) (1989 – )
• International Academy for Pathology (1990 – )
• Swiss Society for Pathology (1996 – )
• German Society for Pathology (1996 – )
• American Association of Cancer Research
  (1996 – )
• United States and Canadian Academy of Pathology (2001 – )
• Swiss Society for Senology (2001 – )
• Swiss Society for Molecular Pathology (2001 – )
• Swiss Medical Association (FMH) (2003 – )

Other professional activities

• German Society for Pathology, Executive Commitee (2007 – ) 
• German Society for Pathology, Secretary-Treasurer (2009 – ) 
• Examination Board of the FMH Pathology, President (2004 – 2008)
• Swiss Group for Clinical Cancer Research (SAKK), Executive Committee (2004 – )
• Competence Center ‘Systems Physiology and Metabolic Diseases’, Executive Board (2005 – ) 
• Cancer Network Zürich, Steering Committee (2004 – ) 
• United States and Canadian Academy of Pathology; Short Course Director: “Renal Neoplasia” (together with Prof. J. Eble, Indianapolis) (2005 – 2008)
• "Renal Neoplasia", Director (together with Prof. J. Eble, Indianapolis) (2005 – 2008)
• Center for Microscopy and Image Analysis, University Zürich, Steering Committee (2006 – )

Foundations, Advisory Council

• Stiftung Julius Müller zur Unterstützung der Krebsforschung, President (2004 – )
• Stiftung Lydia Hochstrasser, President (2004 – 2007)
• Stiftung für die Forschung in der Onkologie, Member (2005 – )
• Stiftung Walter Honegger, Member (2004 – )
• Ida de Pottère-Leupold und Dr. jur. E. de Pottère-Stiftung, Member (2004 – )
• Swiss Cancer League and Oncosuisse, Member Scientific Commitee (2005 – )
• Kantonal-Zürcherische Krebskommission, Member (2007 – )
• Charles Rodolphe Brupbacher Foundation, Advisory Board (2006 – ); Organizer of the Symposium of the CRB Foundation (2007, 2009)

Research Activities

• Assay Development in surgical pathology
• “Obesity-driven Cancer” Project of the “Competence Center for Systems Physiology and Metabolic Disease (CC-SPMD)”
• Identification of Cancer testis (CT-) specific antigens in the Antigen Discover Collaborative, a joint program of the Cancer Research Institute and the Ludwig Institute for Cancer Research (together with the Clinics for Oncology, Zürich)
• LiverX Project of the “Competence Center for Systems Physiology and Metabolic Disease (CC-SPMD)” within SystemsX

Grants

• Deutsche Forschungsgemeinschaft (DFG)
• Swiss National Science Foundation
• Swiss Cancer League
• Cancer Research Switzerland
• Basel Cancer League
• Zürich Cancer League

Most important recent publications

• Probst-Hensch NM, Steiner JH, Schraml P, Varga Z, Zurrer-Hardi U, Storz M, Korol D, Fehr MK, Fink D, Pestalozzi BC, Lutolf UM, Theurillat JP, Moch H. IGFBP2 and IGFBP3 protein expressions in human breast cancer: association with hormonal factors and obesity. Clin Cancer Res 2010;16(3):1025-32. (IF: 6.48)

• Nilsson KP, Ikenberg K, Aslund A, Fransson S, Konradsson P, Rocken C, Moch H, Aguzzi A. Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy. Am J Pathol 2010;176(2):563-74. (shared last authorship) (IF: 5.69)

• Dellas A, Jundt G, Sartorius G, Schneider M, Moch H. Combined PTEN and p27kip1 protein expression patterns are associated with obesity and prognosis in endometrial carcinomas. Clin Cancer Res 2009;15(7):2456-62 (IF: 6.48)

• Beroukhim R, Brunet JP, Di Napoli A, Mertz KD, Seeley A, Pires MM, Linhart D, Worrell RA, Moch H, Rubin MA, Sellers WR, Meyerson M, Linehan WM, Kaelin WG, Jr., Signoretti S. Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res 2009;69(11):4674-81 (IF: 7.51)

• Luu VD, Boysen G, Struckmann K, Casagrande S, von Teichman A, Wild PJ, Sulser T, Schraml P, Moch H. Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clin Cancer Res 2009;15(10):3297-304. (IF: 6.48)

• Riener MO, Stenner F, Liewen H, Soll C, Breitenstein S, Pestalozzi BC, Samaras P, Probst-Hensch N, Hellerbrand C, Mullhaupt B, Clavien PA, Bahra M, Neuhaus P, Wild P, Fritzsche F, Moch H, Jochum W, Kristiansen G. Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas. Hepatology 2009;49(5):1602-9. (IF: 11.35)

• Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, Schraml P, Moch H. pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. J Pathol 2008;214(4):464-71. (IF: 5.12)

• Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H, Krek W. pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J 2008: 27: 1747-57. (IF 8.29)

• Amin MB, Paner GP, Alvarado-Cabrero I, Young AN, Stricker HJ, Lyles RH, Moch H. Chromophobe Renal Cell Carcinoma: Histomorphologic Characteristics and Evaluation of Conventional Pathologic Prognostic Parameters in 145 Cases. Am J Surg Pathol 2008;32(12):1822-34. (IF 4.02)

• Thoma CR, Frew IJ, Hoerner CR, Montani M, Moch H, Krek W. pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat Cell Biol 2007;9(5):588-95. (IF 17.77)

• Zhao J, Yart A, Frigerio S, Perren A, Schraml P, Weisstanner C, Stallmach T, Krek W, Moch H. Sporadic human renal tumors display frequent allelic imbalances and novel mutations of the HRPT2 gene. Oncogene 2007;26(23):3440-9 (IF 7.21)

• Thomas RK, Baker AC, Debiasi RM, Winckler W, et al.: High-throughput oncogene mutation profiling in human cancer. Nat Genet 2007;39(3):347-51 (IF 30.25)

• Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., and Krek, W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL, Nature 2003; 425:307-311 (IF 31.43)

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